HCID 69682309, compound → HCID 10180469, compound

Participants

Reaction Steps

200 mg of (RS)-4-[3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-oct-1-enyl]-benzoic acid were dissolved in 20 ml of absolute ethanol and 60 mg of 30% Pd on carbon were added. The reaction flask was purged from the oxygen by vacuum and hydrogen filling (two times). The mixture was subjected to atmospheric H2 pressure for 6 hours. The reaction mixture was filtered on a pad of Celite and concentrated in vacuo. The product was purified by preparative tic (SiO2, 5% methanol/methylene chloride), giving 140 mg of the titled compound as a white solid. 1H NMR (CDCl3): 7.99 (d, J=8.3 Hz, 2H), 7.21 (d, J=8.1 Hz, 1H), 7.19 (d, J=8.3 Hz, 2H), 7.02 (d, J=1.8 Hz, 1H), 6.89 (dd, J=8.1, 1.8 Hz, 1H), 2.60-2.35 (m, 3H), 2.05-1.80 (m, 2H), 1.68 (s, 4H), 1.60-1.45 (m, 2H), 1.28 (s, 3H), 1.27 (s, 9H), 1.30-1.10 (m, 6H), 0.82 (t, J=6.7 Hz, 3H).

Provenance & Evidence