3-Nitrophthalic anhydride → HCID 18178019, compound

HRID 394957Notes

Reaction equation

HRID 394957 reaction equation
[N+:1]([C:4]1[CH:14]=[CH:13][CH:12]=[C:6]2[C:7]([O:9][C:10](=[O:11])[C:5]=12)=O)([O-:3])=[O:2].[F:15][C:16]([F:32])([O:23][C:24]1[CH:30]=[CH:29][C:27]([CH3:31])([NH2:28])[CH2:26][CH:25]=1)[CH:17]([F:22])[C:18]([F:21])([F:20])[F:19]>C(O)(=O)C>[F:15][C:16]([F:32])([O:23][C:24]1[CH:25]=[CH:26][C:27]([N:28]2[C:10](=[O:11])[C:5]3=[C:4]([N+:1]([O-:3])=[O:2])[CH:14]=[CH:13][CH:12]=[C:6]3[C:7]2=[O:9])([CH3:31])[CH2:29][CH:30]=1)[CH:17]([F:22])[C:18]([F:19])([F:20])[F:21]

Participants

4

Reactant 2

HCID 216313-Nitrophthalic anhydrideHCID 18178018HCID 18178018, compound

Product 1

HCID 18178019HCID 18178019, compoundYield 98.5%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

In 30 ml of acetic acid were dissolved 1.93 g of 3-nitrophthalic anhydride and 2.73 g of 4-(1,1,2,3,3,3-hexafluoropropoxy)-1-methylaniline. A reaction was carried out for 3 hours with heating under reflux. After completion of the reaction, the solvent was distilled off under reduced pressure, and the residue was washed with a mixture of ether and hexane, whereby 4.4 g of the objective compound was obtained.

Workup

  1. temperaturewith heating
  2. temperatureunder reflux
  3. customAfter completion of the reaction
  4. distillationthe solvent was distilled off under reduced pressure
  5. washthe residue was washed with a mixture of ether and hexane

Sources & evidence

ORD record
ord-39d947ffa188437d8ff32f003680bd5b
Source dataset
uspto-grants-2003_08
Patent number
US06603044B1

Reaction notes

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