Diethyl Ether → HCID 22468741, compound

Participants

Reaction Steps

A mixture of 1.5 g of tert-butyl 4-(tert-butyldimethylsilanyloxymethyl)-4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]piperidine-1-carboxylate in 6.5 cm3 of 5N hydrochloric acid dissolved in dioxane and 30 cm3 of dioxane was stirred at a temperature in the region of 20° C. for 17 hours. 100 cm3 of diethyl ether were added to the reaction mixture. The precipitate formed was filtered off to give 1.24 g of {4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]piperidin-4-yl}methanol dihydrochloride in the form of a pale yellow solid.

Provenance & Evidence