反应详情

温度

20 °C

1.2 cm3 of thionyl chloride in 5 cm3 of dichloromethane were added to a solution of 1.55 g of ethyl 4-[3-(3-fluoroquinolin-4-yl)propyl]-1-(2-hydroxy-ethyl)piperidine-4-carboxylate in 35 cm3 of dichloromethane, with stirring at a temperature in the region of 20° C. After stirring for 42 hours at a temperature in the region of 20° C., the reaction mixture was concentrated to dryness under reduced pressure (1.2 kPa) at about 50° C. The foam obtained was taken up in 3 times 100 cm3 of cyclohexane, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40° C. and oven-dried under reduced pressure (10 kPa) at a temperature in the region of 20° C. 1.8 g of ethyl 1-(2-chloroethyl)-4-[3-(3-fluoroquinolin-4-yl)propyl]piperidine-4-carboxylate monohydrochloride were obtained in the form of a cream-colored solid.

1. stirringAfter stirring for 42 hours at a temperature in the region of 20° C.
2. concentrationthe reaction mixture was concentrated to dryness under reduced pressure (1.2 kPa) at about 50° C
3. customThe foam obtained
4. concentrationconcentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40° C.
5. customoven-dried under reduced pressure (10 kPa) at a temperature in the region of 20° C