Thionyl Chloride → HCID 22469796, compound

Participants

Reaction Conditions

Reaction Steps

5.73 cm3 of thionyl chloride were added dropwise to a suspension of 0.6 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-(2-hydroxyethyl)piperidine-4-carboxylate in 10 cm3 of dichloromethane with stirring in the region of 20° C., and the mixture was stirred for 24 hours at a temperature in the region of 20° C. The reaction mixture was concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40° C. The residue was taken up in 3 times 30 cm3 of cyclohexane and evaporated to dryness as under the above conditions. 0.67 g of ethyl 1-(2-chloroethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate dihydrochloride was obtained in the form of a beige-colored solid.

Provenance & Evidence