Ethanol → 6-Ethynyl-1-(iso-propyl-methyl-amino)-4,4-dimethyl-1,2,3,4-tetrahydronaphthalene

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Reaction Steps

Following general procedure I and using 4-[5-(iso-propyl-methyl-amino) -8,8-dimethyl-5,6,7,8-tetrahydronaphthalene-2-ylethynyl)]-benzoic acid ethyl ester (Compound 25, 0.04 g, 0.01 mmol), ethanol (2 mL), tetrahydrofuran (1 mL) and 1M aqueous sodium hydroxide solution (1 mL) followed by recrystallization from diethylether-hexane, the title compound was obtained as an off-white solid (0.010 g, 27%).

Provenance & Evidence