Sodium Chloride → 2-(4-{[(3,4-Dihydro-2H-1-benzopyran-2-yl)methyl]amino}butyl)-1H-1lambda~6~,2-benzothiazole-1,1,3(2H)-trione--hydrogen chloride (1/1)

HRID 395234Notes

Reaction equation

HRID 395234 reaction equation
[Na+].[Cl-:2].[CH:3]1[CH:4]=[CH:5][C:6]2[O:12][C@@H:11]([CH2:13][NH:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]3[S:28](=[O:30])(=[O:29])[C:27]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[C:20]3=[O:21])[CH2:10][CH2:9][C:7]=2[CH:8]=1>>[CH2:10]1[C@H:11]([CH2:13][NH:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]2[S:28](=[O:30])(=[O:29])[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:20]2=[O:21])[O:12][C:6]2[C:7](=[CH:8][CH:3]=[CH:4][CH:5]=2)[CH2:9]1.[ClH:2]

Participants

3

Reactant 2

HCID 5234Sodium ChlorideHCID 198757Repinotan

Product 1

HCID 1987562-(4-{[(3,4-Dihydro-2H-1-benzopyran-2-yl)methyl]amino}butyl)-1H-1lambda~6~,2-benzothiazole-1,1,3(2H)-trione--hydrogen chloride (1/1)

Procedure

A ready-to-use infusion solution is prepared from the freeze-dried product according to Example 1 by reconstituting the lyophilizate with the aid of a 0.9% by weight NaCl solution and then diluting with this solution to a total volume of 500 ml. The ready-to-use solution is chemically stable on storage for at least 30 h at room temperature, i.e. the solution then still contains at least 90% unchanged repinotan.

Workup

  1. customA ready-to-use infusion solution is prepared from the freeze-dried product
  2. additiondiluting with this solution to a total volume of 500 ml
  3. waitThe ready-to-use solution is chemically stable on storage for at least 30 h at room temperature

Sources & evidence

ORD record
ord-939cee97267e4c9a884f9f536969426b
Source dataset
uspto-grants-2003_08
Patent number
US06605255B2

Reaction notes

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