反应详情

8-(4-Hydroxy-bicyclo[2.2.2]oct-1-yl)-3-propyl-3,7-dihydro-purine-2,6-dione (500 mg, 1.57 mmol) was dissolved in 10 mL of pyridine. P4S10 (1.05 g, 1.5 eq) was added and the reaction mixture was stirred under reflux for 6 h. The reaction mixture was then cooled to rt and quenched slowly with 5 mL of H2O. The mixture was then acidified at 0° C. to pH 5 with 6 N HCl. The aqueous layer was extracted with EtOAc. The combined organic layer was dried (Na2SO4) and concentrated under reduced pressure. Purification by preparative HPLC afforded 100 mg of the titled compound.

1. temperatureunder reflux for 6 h
2. customquenched slowly with 5 mL of H2O
3. customwas then acidified at 0° C. to pH 5 with 6 N HCl
4. extractionThe aqueous layer was extracted with EtOAc
5. dry with materialThe combined organic layer was dried (Na2SO4)
6. concentrationconcentrated under reduced pressure
7. customPurification by preparative HPLC