HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Phenylenediamine → ethyl 2-(1H-1,3-benzodiazol-2-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | Ethyl 3-ethoxy-3-iminopropionate hydrochloride | HCID 75345 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl 2-(1H-1,3-benzodiazol-2-yl)acetate | HCID 308071 | — |
Reaction Steps
A solution of 1,2-phenylenediamine (1.0 eq) and ethyl 3-ethoxy-3-iminopropanoate hydrochloride (1.3 eq) in ethanol was stirred at 90° C. overnight. The reaction was cooled to room temperature and the solvent was removed in vacuo. Water and CH2Cl2 were added to the residue. The organic layer was separated, dried over Na2SO4 and the solvent removed. The solid recovered was used without purification. LC/MS m/z 205.2 (MH+), Rf 1.44 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06605617B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-258dce652341484b8f9fd27e88f3377b |
| Source note | uspto-grants-2003_08 |