HCID 12988784, compound → 4-[2-(Morpholin-4-yl)ethoxy]benzene-1,2-diamine

HRID 395338Notes

Reaction equation

HRID 395338 reaction equation
[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[C:12]([N+:17]([O-])=O)[CH:11]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>CCO.[Pd]>[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]([NH2:17])[C:13]([NH2:16])=[CH:14][CH:15]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 12988784HCID 12988784, compound

Product 1

HCID 129887854-[2-(Morpholin-4-yl)ethoxy]benzene-1,2-diamine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution 4-(2-morpholin-4-ylethoxy)-2-nitrophenylamine (1.0 eq) in EtOH was added Pd/C (0.1 eq). The reaction vessel was repeatedly purged with nitrogen, then stirred under a hydrogen atmosphere (1 atm) for 18 hours. The product was filter ed through a Celite plug, and the plug washed with EtOH. The diamine was used without purification. LC/MS m/z 238.3 (MH+), Rf 0.295 minutes.

Workup

  1. customThe reaction vessel was repeatedly purged with nitrogen
  2. filtrationThe product was filter
  3. washthe plug washed with EtOH
  4. customThe diamine was used without purification

Sources & evidence

ORD record
ord-f4ca8b85f75d47eaaf3115c77a1dab1e
Source dataset
uspto-grants-2003_08
Patent number
US06605617B2

Reaction notes

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