4-Tert-Butylbenzenethiol → Methyl 5-(4-t-Butylphenylthiomethyl)-2-(difluoromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate

HRID 395396Notes

Reaction equation

HRID 395396 reaction equation
Cl[CH2:2][C:3]1[C:4]([CH2:20][CH:21]([CH3:23])[CH3:22])=[C:5]([C:16]([O:18][CH3:19])=[O:17])[C:6]([CH:13]([F:15])[F:14])=[N:7][C:8]=1[C:9]([F:12])([F:11])[F:10].[C:24]([C:28]1[CH:33]=[CH:32][C:31]([SH:34])=[CH:30][CH:29]=1)([CH3:27])([CH3:26])[CH3:25]>>[C:24]([C:28]1[CH:29]=[CH:30][C:31]([S:34][CH2:2][C:3]2[C:4]([CH2:20][CH:21]([CH3:23])[CH3:22])=[C:5]([C:16]([O:18][CH3:19])=[O:17])[C:6]([CH:13]([F:15])[F:14])=[N:7][C:8]=2[C:9]([F:12])([F:11])[F:10])=[CH:32][CH:33]=1)([CH3:27])([CH3:25])[CH3:26]

Participants

3

Reactant 2

HCID 754544-Tert-ButylbenzenethiolHCID 22668817Methyl 2-(difluoromethyl)-5-(chloromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate

Product 1

HCID 9805544Methyl 5-(4-t-Butylphenylthiomethyl)-2-(difluoromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate

Procedure

Reaction of methyl 5-chloromethyl-2-(difluoromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate (example 3 of U.S. Pat. No. 5,169,432) with 4-t-butylbenzenethiol according to the procedure of example 29 of U.S. Pat. No. 5,169,432 yielded the product as an oil.

Sources & evidence

ORD record
ord-d9e0fdb633e9499fab94536c60667803
Source dataset
uspto-grants-2003_08
Patent number
US06605624B1

Reaction notes

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