Methyl iodide → HCID 9910999, compound

HRID 395408Notes

Reaction equation

[F:1][CH:2]([F:28])[C:3]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[C:7]([CH2:13][CH:14]([CH3:16])[CH3:15])[C:6]([CH:17]([C:19]2[S:23][N:22]=[CH:21][CH:20]=2)[OH:18])=[C:5]([C:24]([F:27])([F:26])[F:25])[N:4]=1.[CH3:29]I>>[F:28][CH:2]([F:1])[C:3]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[C:7]([CH2:13][CH:14]([CH3:15])[CH3:16])[C:6]([CH:17]([O:18][CH3:29])[C:19]2[S:23][N:22]=[CH:21][CH:20]=2)=[C:5]([C:24]([F:27])([F:26])[F:25])[N:4]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 53839148HCID 53839148, compound

Product 1

HCID 9910999HCID 9910999, compound

Procedure

Methyl 2-(difluoromethyl)-5-[(isothiazol-5-yl) hydroxymethyl]-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate (prepared by the procedure similar to example H of U.S. Pat. No. 5,260,262) was alkylated with methyl iodide by the procedure in example 61 of U.S. Pat. No. 5,169,432.

Sources & evidence

ORD record: ord-7f891953d6654bcf886e2a5a1da943d9
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06605624B1

Reaction notes

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