Potassium Hydroxide → 2-(3,4,5-Trimethoxyphenyl)pyridine-4-carboxylic acid

HRID 395424Notes

Reaction equation

HRID 395424 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:14]=[C:15]([CH:21]=[CH:22][N:23]=2)[C:16]([O:18]CC)=[O:17])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[OH-].[K+]>C(O)C>[CH3:12][O:11][C:7]1[CH:6]=[C:5]([C:13]2[CH:14]=[C:15]([CH:21]=[CH:22][N:23]=2)[C:16]([OH:18])=[O:17])[CH:4]=[C:3]([O:2][CH3:1])[C:8]=1[O:9][CH3:10]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 16125879Ethyl 2-(3,4,5-trimethoxyphenyl)pyridine-4-carboxylate

Product 1

HCID 120434852-(3,4,5-Trimethoxyphenyl)pyridine-4-carboxylic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl 2-(3,4,5-trimethoxyphenyl)isonicotinate (3.17 g) in ethanol (40 mL) was added 10% potassium hydroxide (2.42 g). The mixture was stirred at room temperature for 5 hours and evaporated. Water was added to the residue and pH was adjusted to 7. White precipitates of the title compound were collected by filtration and the compound was used for next step without further purification.

Workup

  1. customevaporated
  2. additionWater was added to the residue and pH
  3. customWhite precipitates of the title compound
  4. filtrationwere collected by filtration
  5. customthe compound was used for next step without further purification

Sources & evidence

ORD record
ord-c087720844864683b5944d179db668a9
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

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