反应详情

To a solution of ethyl 2-(4-chloro-3,5-dimethoxyphenyl)isonicotinate (8.55 g) in ethanol (80 mL) was added 2 M sodium hydroxide (100 mL). The mixture was refluxed for 30 min and evaporated. The aqueous layer was neutralized by 1 M hydrochloric acid and precipitates were dissolved in a mixed solvent of ethyl acetate-THF (3:1). After drying over anhydrous sodium sulfate, the solvent was evaporated to give the title compound.

1. temperatureThe mixture was refluxed for 30 min
2. customevaporated
3. customprecipitates
4. dissolutionwere dissolved in a mixed solvent of ethyl acetate-THF (3:1)
5. dry with materialAfter drying over anhydrous sodium sulfate
6. customthe solvent was evaporated