Tetrafluoro-m-phenylenediamine dihydrochloride → HCID 22558046, compound

HRID 395442Notes

Reaction equation

HRID 395442 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][N:20]=[C:19]([C:23]4[CH:28]=[C:27]([O:29][CH3:30])[C:26]([O:31][CH3:32])=[C:25]([O:33][CH3:34])[CH:24]=4)[CH:18]=3)[CH2:12][CH2:11]2)=[CH:5][CH:4]=1.[CH3:35][O:36][C:37]1[CH:38]=[C:39]([C:47]2[CH:48]=[C:49]([CH:52]=[CH:53][CH:54]=2)[CH2:50][Cl:51])[CH:40]=[C:41]([O:45][CH3:46])[C:42]=1[O:43][CH3:44].C1(N)C(F)=C(F)C(F)=C(N)C=1F.[ClH:67].Cl>>[ClH:51].[ClH:67].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][N:20]=[C:19]([C:23]4[CH:24]=[C:25]([O:33][CH3:34])[C:26]([O:31][CH3:32])=[C:27]([O:29][CH3:30])[CH:28]=4)[CH:18]=3)[CH2:14][CH2:15]2)[CH2:50][C:49]2[CH:52]=[CH:53][CH:54]=[C:47]([C:39]3[CH:40]=[C:41]([O:45][CH3:46])[C:42]([O:43][CH3:44])=[C:37]([O:36][CH3:35])[CH:38]=3)[CH:48]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 120211573-(3,4,5-Trimethoxyphenyl)benzyl chlorideHCID 120431454-(p-Anisidino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine

Product 1

HCID 22558046HCID 22558046, compound

Procedure

4-(p-Anisidino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine (139 mg) and 3-(3,4,5-trimethoxyphenyl)benzyl chloride (114 mg) were condensed by the same manner as described in Example 9. Yellow oil of a free base was converted to a dihydrochloride which gave the title compound as yellow powder.

Workup

  1. customcondensed by the same manner

Sources & evidence

ORD record
ord-559f38fab0004c9ab7eca42532de07fb
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

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