Ethyl 2-chloroisonicotinate → Ethyl 2-(3,5-dimethoxy-4-isopropoxyphenyl)isonicotinate

HRID 395448Notes

Reaction equation

HRID 395448 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[C:7]([O:13][CH3:14])[C:8]=1[O:9][CH:10]([CH3:12])[CH3:11].Cl[C:19]1[CH:20]=[C:21]([CH:27]=[CH:28][N:29]=1)[C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:19]2[CH:20]=[C:21]([CH:27]=[CH:28][N:29]=2)[C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:6]=[C:7]([O:13][CH3:14])[C:8]=1[O:9][CH:10]([CH3:12])[CH3:11]

Participants

3

Reactant 2

HCID 2762942Ethyl 2-chloroisonicotinateHCID 224855944-Isopropoxy-3,5-dimethoxyphenylboronic acid

Product 1

HCID 22557851Ethyl 2-(3,5-dimethoxy-4-isopropoxyphenyl)isonicotinate

Procedure

To a solution of 3,5-dimethoxy-4-isopropoxyphenylboronic acid (1.23 g) and ethyl 2-chloroisonicotinate (0.95 g) were condensed in the same manner as described in Preparation Example 1 to give the title compound.

Workup

  1. customcondensed in the same manner
  2. customas described in Preparation Example 1

Sources & evidence

ORD record
ord-6547942edf7c49d3a2d5675c746f0235
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

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