4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine → HCID 22557792, compound

HRID 395480Notes

Reaction equation

HRID 395480 reaction equation
[CH2:1]([N:3]([CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)[CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([C:11]2[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[C:13]([O:21][CH3:22])[CH:12]=2)[CH:6]=1)[CH3:2].[Cl:29][CH2:30][C:31]1[CH:36]=[CH:35][N:34]=[C:33]([C:37]2[CH:42]=[C:41]([O:43][CH3:44])[C:40]([O:45][CH3:46])=[C:39]([O:47][CH3:48])[CH:38]=2)[CH:32]=1>>[ClH:29].[ClH:29].[ClH:29].[ClH:29].[CH2:1]([N:3]([CH:23]1[CH2:24][CH2:25][N:26]([CH2:30][C:31]2[CH:36]=[CH:35][N:34]=[C:33]([C:37]3[CH:42]=[C:41]([O:43][CH3:44])[C:40]([O:45][CH3:46])=[C:39]([O:47][CH3:48])[CH:38]=3)[CH:32]=2)[CH2:27][CH2:28]1)[CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([C:11]2[CH:12]=[C:13]([O:21][CH3:22])[C:14]([O:19][CH3:20])=[C:15]([O:17][CH3:18])[CH:16]=2)[CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 120192374-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridineHCID 22558029HCID 22558029, compound

Product 1

HCID 22557792HCID 22557792, compound

Procedure

4-[N-ethyl-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amino]piperidine (65 mg) and 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (50 mg) were condensed in the same manner as described in Example 2. The title compound was obtained after converting a free base to a tetrahydrochloride.

Workup

  1. customcondensed in the same manner

Sources & evidence

ORD record
ord-bbb9c25440c4482e9217b4f125746aa2
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

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