4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine → HCID 22558081, compound

HRID 395482Notes

Reaction equation

HRID 395482 reaction equation
[CH:1]1([NH:7][CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][N:18]=[C:17]([C:21]4[CH:26]=[C:25]([O:27][CH3:28])[C:24]([O:29][CH3:30])=[C:23]([O:31][CH3:32])[CH:22]=4)[CH:16]=3)[CH2:10][CH2:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:33][CH2:34][C:35]1[CH:40]=[CH:39][N:38]=[C:37]([C:41]2[CH:46]=[C:45]([O:47][CH3:48])[C:44]([O:49][CH3:50])=[C:43]([O:51][CH3:52])[CH:42]=2)[CH:36]=1>>[ClH:33].[ClH:33].[ClH:33].[ClH:33].[CH:1]1([N:7]([CH:8]2[CH2:9][CH2:10][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][N:18]=[C:17]([C:21]4[CH:22]=[C:23]([O:31][CH3:32])[C:24]([O:29][CH3:30])=[C:25]([O:27][CH3:28])[CH:26]=4)[CH:16]=3)[CH2:12][CH2:13]2)[CH2:34][C:35]2[CH:40]=[CH:39][N:38]=[C:37]([C:41]3[CH:46]=[C:45]([O:47][CH3:48])[C:44]([O:49][CH3:50])=[C:43]([O:51][CH3:52])[CH:42]=3)[CH:36]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 120192374-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridineHCID 22557873HCID 22557873, compound

Product 1

HCID 22558081HCID 22558081, compound

Procedure

4-(Cyclohexylamino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine (342 mg) and 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (252 mg) were reacted in the same manner as described in Preparation Example 6. The title compound was obtained after converting the product to a tetrahydrochloride.

Workup

  1. customas described in Preparation Example 6

Sources & evidence

ORD record
ord-8c5df8f1f30d45479464d0992e403808
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

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