1,4-Dioxa-8-azaspiro(4.5)decane → HCID 18342989, compound

HRID 395485Notes

Reaction equation

HRID 395485 reaction equation
[CH2:1]1[O:10][C:4]2([CH2:9][CH2:8][NH:7][CH2:6][CH2:5]2)[O:3][CH2:2]1.[Cl:11][C:12]1[C:17]([O:18][CH3:19])=[CH:16][C:15]([C:20]2[CH:25]=[C:24]([CH2:26]Cl)[CH:23]=[CH:22][N:21]=2)=[CH:14][C:13]=1[O:28][CH3:29]>>[CH2:1]1[O:10][C:4]2([CH2:9][CH2:8][N:7]([CH2:26][C:24]3[CH:23]=[CH:22][N:21]=[C:20]([C:15]4[CH:16]=[C:17]([O:18][CH3:19])[C:12]([Cl:11])=[C:13]([O:28][CH3:29])[CH:14]=4)[CH:25]=3)[CH2:6][CH2:5]2)[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 22557787HCID 22557787, compound

Product 1

HCID 18342989HCID 18342989, compound

Procedure

4-Piperidone ethylene ketal (573 mg) and 2-(4-chloro-3,5-dimetoxyphenyl)-4-chloromethylpyridine (1.19 g) were condensed in the same manner as described in Example 2 to give the title compound.

Workup

  1. customcondensed in the same manner

Sources & evidence

ORD record
ord-4e9bc00bf6704966943d525044d7ccdc
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

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