HCID 22557787, compound → HCID 22558020, compound

HRID 395487Notes

Reaction equation

HRID 395487 reaction equation
[NH:1]([CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][N:18]=[C:17]([C:21]3[CH:26]=[C:25]([O:27][CH3:28])[C:24]([Cl:29])=[C:23]([O:30][CH3:31])[CH:22]=3)[CH:16]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:32][C:33]1[C:38]([O:39][CH3:40])=[CH:37][C:36]([C:41]2[CH:46]=[C:45]([CH2:47]Cl)[CH:44]=[CH:43][N:42]=2)=[CH:35][C:34]=1[O:49][CH3:50]>>[ClH:29].[ClH:32].[ClH:29].[Cl:29][C:24]1[C:23]([O:30][CH3:31])=[CH:22][C:21]([C:17]2[CH:16]=[C:15]([CH2:14][N:11]3[CH2:12][CH2:13][CH:8]([N:1]([CH2:47][C:45]4[CH:44]=[CH:43][N:42]=[C:41]([C:36]5[CH:37]=[C:38]([O:39][CH3:40])[C:33]([Cl:32])=[C:34]([O:49][CH3:50])[CH:35]=5)[CH:46]=4)[C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[CH2:9][CH2:10]3)[CH:20]=[CH:19][N:18]=2)=[CH:26][C:25]=1[O:27][CH3:28]

Participants

3

Reactant 2

HCID 22557787HCID 22557787, compoundHCID 22557918HCID 22557918, compound

Product 1

HCID 22558020HCID 22558020, compound

Procedure

4-Anilino-1-[[2-(4-chloro-3,5-dimethoxyphenyl)pyridin-4-yl]methyl]piperidine (230 mg) and 2-(4-chloro-3,5-dimethoxyphenyl)-4-chloromethylpyridine (157 mg) were condensed in the same manner as described in Example 9. The title compound was obtained as yellow powder after converting a free base to a trihydrochloride.

Workup

  1. customcondensed in the same manner

Sources & evidence

ORD record
ord-be8f886a6ab24f7eaf3c7066c7ec663b
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

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