2-(3,4,5-Trimethoxyphenyl)benzyl chloride → 4-[N-(indan-5-yl)-N-[2-(3,4,5-trimethoxyphenyl)benzyl]amino]1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine dihydrochloride

Participants

Role	Name	HCID	Charge
Reactant	2-(3,4,5-Trimethoxyphenyl)benzyl chloride	HCID 12016329	—
Reactant	4-(5-Indanylamino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine	HCID 22557857	—
Product	4-[N-(indan-5-yl)-N-[2-(3,4,5-trimethoxyphenyl)benzyl]amino]1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine dihydrochloride	HCID 22558072	—

Reaction Steps

4-(5-Indanylamino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine (142 mg) and 2-(3,4,5-trimethoxyphenyl)benzyl chloride (114 mg) were condensed in the same manner as described in Example 9. The title compound was obtained as yellow powder after converting a free base to a dihydrochloride.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06605620B1
Source dataset	uspto-grants-2003_08
ORD ID	ord-5769b156fce047b1bba0242bab72b18d
Source note	uspto-grants-2003_08