4-(3,4,5-Trimethoxyphenyl)benzyl chloride → 4-[N-(indan-5-yl)-N-[4-(3,4,5-trimethoxyphenyl)benzyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine dihydrochloride

Participants

Role	Name	HCID	Charge
Reactant	4-(3,4,5-Trimethoxyphenyl)benzyl chloride	HCID 12021158	—
Reactant	4-(5-Indanylamino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine	HCID 22557857	—
Product	4-[N-(indan-5-yl)-N-[4-(3,4,5-trimethoxyphenyl)benzyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine dihydrochloride	HCID 22557859	—

Reaction Steps

4-(5-Indanylamino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine (143 mg) and 4-(3,4,5-trimethoxyphenyl)benzyl chloride (114 mg) were condensed in the same manner as described in Example 9. The title compound was obtained as yellow powder after converting a free base to a dihydrochloride.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06605620B1
Source dataset	uspto-grants-2003_08
ORD ID	ord-89e0d51d4b624d77b7a1287ffe46bc0f
Source note	uspto-grants-2003_08