4-Ethoxyaniline → 1-Boc-4-[(4-ethoxyphenyl)amino]-piperidine

HRID 395513Notes

Reaction equation

HRID 395513 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:15][CH2:16][O:17][C:18]1[CH:19]=[CH:20][C:21]([NH2:24])=[CH:22][CH:23]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:24][C:21]2[CH:20]=[CH:19][C:18]([O:17][CH2:16][CH3:15])=[CH:23][CH:22]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 90764-EthoxyanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 225578601-Boc-4-[(4-ethoxyphenyl)amino]-piperidine

Procedure

1-(tert-butoxycarbonyl)-4-piperidinone (5.00 g) and p-phenetidine (3.28 g) was treated in the same manner as described in Preparation Example 37 to give brown powder of the title compound.

Workup

  1. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-c4e97218306147e6960e68e848dbd859
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

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