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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 395519Generated: October 27, 2026

3-(3,4,5-Trimethoxyphenyl)benzyl chloride → 1-(tert-butoxycarbonyl)-4-[N-(4-butoxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]piperidine

https://huagongshe.com/reaction/395519

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(3,4,5-Trimethoxyphenyl)benzyl chlorideHCID 12021157—
Reactant1-(Tert-butoxycarbonyl)-4-(4-butoxyphenylamino)piperidineHCID 22557944—
Product1-(tert-butoxycarbonyl)-4-[N-(4-butoxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]piperidineHCID 22557801—

Reaction Steps

1-(tert-Butoxycarbonyl)-4-[(4-butoxyphenyl)amino]piperidine (697 mg) and 3-(3,4,5-trimethoxyphenyl)benzyl chloride (586 mg) was treated in the same manner as described in Example 9 to give light yellow amorphous of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06605620B1
Source datasetuspto-grants-2003_08
ORD IDord-3d59ba0fa291485ba0832977e08e5f2e
Source noteuspto-grants-2003_08