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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 395523Generated: October 29, 2026

3-(3,4,5-Trimethoxyphenyl)benzyl chloride → 1-(tert-Butoxycarbonyl)4-[N-(3-methoxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]piperidine

https://huagongshe.com/reaction/395523

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(3,4,5-Trimethoxyphenyl)benzyl chlorideHCID 12021157—
ReactantTert-butyl 4-(3-methoxyanilino)piperidine-1-carboxylateHCID 22557965—
Product1-(tert-Butoxycarbonyl)4-[N-(3-methoxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]piperidineHCID 22557886—

Reaction Steps

4-(m-Anisidino)-1-(tert-butoxycarbonyl)piperidine (613 mg) and 3-(3,4,5-trimethoxyphenyl)benzyl chloride (586 mg) was treated in the same manner as described in Preparation Example 9 to give light yellow amorphous of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06605620B1
Source datasetuspto-grants-2003_08
ORD IDord-c93acf57f68a40c58e39ea143f3bcecd
Source noteuspto-grants-2003_08