2-Methoxyaniline → tert-Butyl 4-((2-methoxyphenyl)amino)piperidine-1-carboxylate

HRID 395524Notes

Reaction equation

HRID 395524 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:15][O:16][C:17]1[C:18]([NH2:23])=[CH:19][CH:20]=[CH:21][CH:22]=1>>[CH3:15][O:16][C:17]1[C:18]([NH:23][CH:11]2[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:9][CH2:10]2)=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 70002-MethoxyanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 22557919tert-Butyl 4-((2-methoxyphenyl)amino)piperidine-1-carboxylate

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (4.78 g) and o-anisidine (2.96 g) were condensed in the same manner as described in Preparation Example 37 to give the title compound.

Workup

  1. customcondensed in the same manner
  2. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-04b6088f5c8b42648d853dff9dd9f4cf
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

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