4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine → 1-(tert-butoxycarbonyl)-4-[N-(2-methoxyphenyl)-N-[[2-(3,4,5-trimethoxyphenyl) pyridin-4-yl]methyl]amino]piperidine

Participants

Role	Name	HCID	Charge
Reactant	4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine	HCID 12019237	—
Reactant	tert-Butyl 4-((2-methoxyphenyl)amino)piperidine-1-carboxylate	HCID 22557919	—
Product	1-(tert-butoxycarbonyl)-4-[N-(2-methoxyphenyl)-N-[[2-(3,4,5-trimethoxyphenyl) pyridin-4-yl]methyl]amino]piperidine	HCID 22557834	—

Reaction Steps

4-(o-Anisidino)-1-(tert-butoxycarbonyl)piperidine (613 mg) and 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (588 mg) was treated in the same manner as described in Example 9 to give light yellow amorphous of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06605620B1
Source dataset	uspto-grants-2003_08
ORD ID	ord-9932f9bf81d7400db173168a528e14a4
Source note	uspto-grants-2003_08