2,3-Dimethoxyaniline → 1-(Tert-butoxycarbonyl)-4-(2,3-dimethoxyphenylamino)piperidine

HRID 395528Notes

Reaction equation

HRID 395528 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:15][O:16][C:17]1[C:23]([O:24][CH3:25])=[CH:22][CH:21]=[CH:20][C:18]=1[NH2:19]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:19][C:18]2[CH:20]=[CH:21][CH:22]=[C:23]([O:24][CH3:25])[C:17]=2[O:16][CH3:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 2396032,3-DimethoxyanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 225578701-(Tert-butoxycarbonyl)-4-(2,3-dimethoxyphenylamino)piperidine

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (4.78 g) and 2,3-dimethoxyaniline (3.68 g) were condensed in the same manner as described in Preparation Example 37 to give the title compound.

Workup

  1. customcondensed in the same manner
  2. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-2d60edcda598439db59e5a80ea3ebd75
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

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