4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine → HCID 22557896, compound

HRID 395529Notes

Reaction equation

HRID 395529 reaction equation
[ClH:1].Cl.[CH3:3][O:4][C:5]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:6]=1[N:13]([CH:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1)[CH2:14][C:15]1[CH:20]=[CH:19][N:18]=[C:17]([C:21]2[CH:26]=[C:25]([O:27][CH3:28])[C:24]([O:29][CH3:30])=[C:23]([O:31][CH3:32])[CH:22]=2)[CH:16]=1.[Cl:39][CH2:40][C:41]1[CH:46]=[CH:45][N:44]=[C:43]([C:47]2[CH:52]=[C:51]([O:53][CH3:54])[C:50]([O:55][CH3:56])=[C:49]([O:57][CH3:58])[CH:48]=2)[CH:42]=1>>[ClH:39].[ClH:1].[ClH:39].[CH3:3][O:4][C:5]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:6]=1[N:13]([CH:33]1[CH2:34][CH2:35][N:36]([CH2:40][C:41]2[CH:46]=[CH:45][N:44]=[C:43]([C:47]3[CH:52]=[C:51]([O:53][CH3:54])[C:50]([O:55][CH3:56])=[C:49]([O:57][CH3:58])[CH:48]=3)[CH:42]=2)[CH2:37][CH2:38]1)[CH2:14][C:15]1[CH:20]=[CH:19][N:18]=[C:17]([C:21]2[CH:26]=[C:25]([O:27][CH3:28])[C:24]([O:29][CH3:30])=[C:23]([O:31][CH3:32])[CH:22]=2)[CH:16]=1

Participants

3

Reactant 2

HCID 120192374-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridineHCID 22557806HCID 22557806, compound

Product 1

HCID 22557896HCID 22557896, compound

Procedure

4-[N-(2,3-Dimethoxyphenyl)-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amino]piperidine Dihydrochloride (113 mg) and 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (59 mg) were condensed in the same manner as described in Example 9. The title compound was obtained as light yellow powder after converting a free base to a trihydrochloride.

Workup

  1. customcondensed in the same manner

Sources & evidence

ORD record
ord-19263247db4a40349cd0f7931bfd1bf7
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

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