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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 395542Generated: October 26, 2026

Tert-butyl 4-((4-bromophenyl)amino)piperidine-1-carboxylate → 4-[N-(4-bromophenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]-1-(tert-butoxycarbonyl)piperidine

https://huagongshe.com/reaction/395542

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-butyl 4-((4-bromophenyl)amino)piperidine-1-carboxylateHCID 11210451—
Reactant3-(3,4,5-Trimethoxyphenyl)benzyl chlorideHCID 12021157—
Product4-[N-(4-bromophenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]-1-(tert-butoxycarbonyl)piperidineHCID 22557800—

Reaction Steps

4-(4-Bromophenyl)amino-1-(tert-butoxycarbonyl)piperidine (711 mg) and 3-(3,4,5-trimethoxyphenyl)benzyl chloride (586 mg) was treated in the same manner as described in Example 9 to give light yellow amorphous of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06605620B1
Source datasetuspto-grants-2003_08
ORD IDord-48e19d078dd84b7e90ad9ee1c46f78aa
Source noteuspto-grants-2003_08