4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine → 1-(tert-butoxycarbonyl)-4-[N-(3,4-difluorophenyl)-N-[[2-(3,4,5-trimethoxyphenyl) pyridin-4-yl]methyl]amino]piperidine

Participants

Role	Name	HCID	Charge
Reactant	4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine	HCID 12019237	—
Reactant	1-Boc-4-[(3,4-difluorophenyl)amino]-piperidine	HCID 22558033	—
Product	1-(tert-butoxycarbonyl)-4-[N-(3,4-difluorophenyl)-N-[[2-(3,4,5-trimethoxyphenyl) pyridin-4-yl]methyl]amino]piperidine	HCID 22558036	—

Reaction Steps

1-(tert-Butoxycarbonyl)-4-[(3,4-difluorophenyl)amino]piperidine (625 mg) and 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (588 mg) was treated in the same manner as described in Example 9 to give light yellow amorphous of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06605620B1
Source dataset	uspto-grants-2003_08
ORD ID	ord-1501d473e4714d2399e05aebb0dff5c6
Source note	uspto-grants-2003_08