Trifluoroacetic acid methylene chloride → 3-[(2-Fluoro-4-iodophenyl)amino]isonicotinohydrazide hydrochloride

HRID 39555Notes

Reaction equation

HRID 39555 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:26]=[N:25][CH:24]=[CH:23][C:11]=1[C:12]([NH:14][NH:15]C(OC(C)(C)C)=O)=[O:13].C(O)(C(F)(F)F)=O.C(Cl)[Cl:35]>>[ClH:35].[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:26]=[N:25][CH:24]=[CH:23][C:11]=1[C:12]([NH:14][NH2:15])=[O:13]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 57649630HCID 57649630, compound

Product 1

HCID 672498793-[(2-Fluoro-4-iodophenyl)amino]isonicotinohydrazide hydrochloride

Procedure

3-[(2-fluoro-4-iodophenyl)amino]isonicotinohydrazide hydrochloride was synthesized from tert-butyl 2-{3-[(2-fluoro-4-iodophenyl)amino]isonicotinoyl}hydrazine-carboxylate (described earlier) by deprotection of the Boc group under acidic conditions (50:50 TFA/DCM). LC/MS [7.11 min; 373 (free base, M+1)]

Workup

  1. customLC/MS [7.11 min; 373 (free base, M+1)]

Sources & evidence

ORD record
ord-0d62df8e6480410e9c3497730f18d545
Source dataset
uspto-grants-2013_09
Patent number
US08524911B2

Reaction notes

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