Aniline → 1-Boc-4-AP

HRID 395553Notes

Reaction equation

HRID 395553 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 6115AnilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 14915021-Boc-4-AP

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (5.00 g) and aniline (2.23 g) was treated in the same manner as described in Preparation Example 37 to give white needles of the title compound.

Workup

  1. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-171470db93de49fcb50c4457e5a2e15e
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

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