Potassium Permanganate → HCID 21917125, compound

HRID 395572Notes

Reaction equation

HRID 395572 reaction equation
[Mn]([O-])(=O)(=O)=[O:2].[K+].[CH:7]([C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][CH:15]=[C:16]2[CH2:19][CH2:20][NH:21][C:22](=[O:30])[CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:11][CH:10]=1)=[O:8]>CC(C)=O.O.CC(C)=O>[C:24]1([CH2:23][C:22]([NH:21][CH2:20][CH2:19][C:16]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:17]=2[CH:18]=[C:9]([C:7]([OH:2])=[O:8])[CH:10]=[CH:11]3)=[O:30])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

5

Reactant 2

HCID 516875Potassium PermanganateHCID 21917242HCID 21917242, compound

Product 1

HCID 21917125HCID 21917125, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 18366337Propan-2-one--water (1/1)Solvent

Procedure

2.7 g of potassium permanganate in 50 ml of an acetone/water mixture (50/50) are added, at ambient temperature, to a solution of 6.88 mmol of the product obtained in Step B in 30 ml of acetone. The solution is stirred for 2 hours at ambient temperature and is then filtered. The filtrate is concentrated under reduced pressure and chromatographed on silica gel to yield the title product.

Workup

  1. filtrationis then filtered
  2. concentrationThe filtrate is concentrated under reduced pressure
  3. customchromatographed on silica gel

Sources & evidence

ORD record
ord-4b171eb5b4ca439d84dacf9b830bdd22
Source dataset
uspto-grants-2003_08
Patent number
US06605632B1

Reaction notes

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