反应详情

The compound obtained in Step B (27.4 mmol) is dissolved in 150 ml of MeOH, and 54.8 mmol of thionyl chloride are added dropwise in the cold state. The mixture is then stirred for 1 hour at ambient temperature and then for 2 hours at reflux. After evaporating off the methanol and the thionyl chloride, the oily residue is taken up in AcOEt, washed with water and then dried over MgSO4. The solvent is evaporated off under reduced pressure and the solid obtained is recrystallised.

1. temperaturefor 2 hours at reflux
2. customAfter evaporating off the methanol
3. washwashed with water
4. dry with materialdried over MgSO4
5. customThe solvent is evaporated off under reduced pressure
6. customthe solid obtained
7. customis recrystallised