反应详情

To the ester obtained in Example 62 (2 mmol), dissolved in methanol (90 ml), there is added aqueous 30% sodium hydroxide solution (30 ml), and the mixture is stirred overnight. After evaporating off the methanol, the temperature of the reaction mixture is lowered with the aid of an ice bath and the mixture is acidified with hydrochloric acid solution (6N). The aqueous phase is extracted with ethyl acetate, and the organic phase is dried over magnesium sulphate and then evaporated to dryness. The residue obtained is recrystallised.

1. customAfter evaporating off the methanol
2. customthe temperature of the reaction mixture is lowered with the aid of an ice bath
3. extractionThe aqueous phase is extracted with ethyl acetate
4. dry with materialthe organic phase is dried over magnesium sulphate
5. customevaporated to dryness
6. customThe residue obtained
7. customis recrystallised