Water → HCID 9858421, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1.19 g (4.10−3 mol) of sodium nitrate in 50 ml of concentrated sulfuric acid is added at 0-5° C., with stirring, to a solution of 3.67 g (13.15.10−2 mol) of 2-pheny-1H-indole-3-butanoic acid in 200 ml of concentrated sulfuric acid. Stirring is maintained at 5° C. for 20 min and the reaction medium is then poured into a mixture of water and ice. The yellow precipitate formed is filtered off and washed on the filter with water and with a small amount of petroleum ether. The product is then dried under reduced pressure and purified by chromatography on silica gel using a hexane/ethyl acetate mixture (1/1) as the eluent to give 1.3 g of the expected product in the form of a yellow solid with a yield of 30%.

Provenance & Evidence