Diethyl fluorophosphate → Potassium diethyl phosphate

HRID 3957Notes

Reaction equation

HRID 3957 reaction equation
[CH2:1]([O:3][P:4](F)([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].C[Si](C)(C)[O-:12].[K+:15]>CCOCC>[CH2:1]([O:3][P:4]([O-:12])([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].[K+:15]

Participants

4

Reactant 2

HCID 67752Diethyl fluorophosphateHCID 23668039Potassium trimethylsilanolate

Product 1

HCID 23663701Potassium diethyl phosphateYield 54.5%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The procedure of Example 1 was followed except that diethylfluorophosphate (0.9 mL, 6.4 mmol) was added by syringe to a slurry of potassium trimethylsilanolate (0.82 g, 6.4 mmol) in dry ether (25 mL) and a 5 h reaction time was used. Potassium diethylphosphate (0.67 g, 54% yield) was isolated as a tan solid: 1H NMR (D2O, DSS) δ 1.2 (t, J=6.9 Hz, CH3, 6H), 3.9 (q, J=6.9 Hz, CH2, 4H).

Workup

  1. customreaction time

Sources & evidence

ORD record
ord-ffca062de04148748522f2a63095a836
Source dataset
uspto-grants-1988_02
Patent number
US04723016

Reaction notes

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