Pyridine → 2-(4-Tert-butylbenzoylamino)-4-nitro-n-(4-methoxyphenyl)benzamide

Participants

Reaction Steps

To a mixture of 2-amino-4-nitro-N-(4-methoxyphenyl)benzamide (2.0 g, 7.0 mmol) and pyridine (0.62 mL, 7.7 mmol) in methylene chloride (40 mL) was added 4-tert-butylbenzoyl chloride (1.44 mL, 7.35 mmol). After stirring for 1.5 h, silica gel (30 g) was added and the solvent evaporated with a stream of nitrogen. The resulting material was chromatographed (silica gel, 5% hexanes/95% methylene chloride to 1.25% ethyl acetate/98.75% methylene chloride) to give 2.41 g (77%) of the title compound as a yellow solid; mp 221° C.

Provenance & Evidence