p-(Methylsulphonyl)benzoic acid → HCID 10622237, compound

HRID 395730Notes

Reaction equation

HRID 395730 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([NH:9][C:10]2[C:11]([NH2:16])=[CH:12][CH:13]=[CH:14][CH:15]=2)=[O:8])=[CH:5][CH:4]=1.[CH3:19][S:20]([C:23]1[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[CH:25][CH:24]=1)(=[O:22])=[O:21]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:9][C:10]2[C:11]([NH:16][C:27](=[O:28])[C:26]3[CH:25]=[CH:24][C:23]([S:20]([CH3:19])(=[O:22])=[O:21])=[CH:31][CH:30]=3)=[CH:12][CH:13]=[CH:14][CH:15]=2)=[O:8])=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 77670p-(Methylsulphonyl)benzoic acidHCID 785232N-(2-Aminophenyl)-4-methoxybenzamide

Product 1

HCID 10622237HCID 10622237, compoundYield 84.4%

Procedure

Using the procedure described in Example 55, Part B, N1-(4-methoxybenzoyl)-1,2-benzenediamine (399 mg, 1.65 mmol) and 4-methylsulfonylbenzoic acid (463 mg, 2.31 mmol) yielded 591 mg (84%) of the title compound as a white solid.

Sources & evidence

ORD record
ord-26072098720446ce86861ccde39935a3
Source dataset
uspto-grants-2003_08
Patent number
US06605626B2

Reaction notes

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