P-Anisidine → N-(4-methoxyphenyl)-2-amino-6-fluorobenzamide

HRID 395784Notes

Reaction equation

HRID 395784 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[NH:12]C(=O)[O:10][C:8](=O)[C:7]=12.[CH3:14][O:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1>>[CH3:14][O:15][C:16]1[CH:22]=[CH:21][C:19]([NH:20][C:8](=[O:10])[C:7]2[C:2]([F:1])=[CH:3][CH:4]=[CH:5][C:6]=2[NH2:12])=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 7732P-AnisidineHCID 27830576-Fluoroisatoic anhydride

Product 1

HCID 18174595N-(4-methoxyphenyl)-2-amino-6-fluorobenzamideYield 84%

Procedure

Using the procedure described in Example 91, Part B, 6-fluoroisatoic anhydride (11 mmol) and 4-methoxyaniline (11 mmol) yielded 2.34 g (84%) of the title compound.

Sources & evidence

ORD record
ord-7d7de953b94c4054abb9ad804c8dca20
Source dataset
uspto-grants-2003_08
Patent number
US06605626B2

Reaction notes

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