Benzoyl chloride → HCID 131724024, compound

HRID 395791Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([CH2:13][O:14][C:15]([NH:17][NH:18][C:19]3[C:20]([NH2:25])=[CH:21][CH:22]=[CH:23][CH:24]=3)=[O:16])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[C:26]([Cl:34])(=O)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[OH2:14].[ClH:34].[CH2:26]([NH:25][C:20]1[C:19]([NH:18][NH:17][C:15]([O:14][CH2:13][CH:10]2[CH2:9][CH2:8][N:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)[CH2:12][CH2:11]2)=[O:16])=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.[CH2:26]([NH:25][C:20]1[C:19]([NH:18][NH:17][C:15]([O:14][CH2:13][CH:10]2[CH2:9][CH2:8][N:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)[CH2:12][CH2:11]2)=[O:16])=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.[ClH:34]

Participants

Reactant 2

HCID 7412Benzoyl chloride

HCID 18174491HCID 18174491, compound

Product 1

HCID 131724024HCID 131724024, compoundYield 90.2%

Procedure

Using the procedure described in Example 48, Part C, N1-[[1-(4-pyridyl)piperidin-4-yl]methoxycarbonylamino]-1,2-benzenediamine (0.61 mmol) and benzoyl chloride (1.2 mmol) yielded 175 mg (61%) of the title compound.

Sources & evidence

ORD record: ord-0ef9646540d24280aa660133495feb46
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06605626B2

Reaction notes

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