3-Fluorobenzoyl chloride → HCID 86759101, compound

HRID 395792Notes

Reaction equation

HRID 395792 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([CH2:13][O:14][C:15]([NH:17][NH:18][C:19]3[C:20]([NH2:25])=[CH:21][CH:22]=[CH:23][CH:24]=3)=[O:16])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[F:26][C:27]1[CH:28]=[C:29]([CH:33]=[CH:34][CH:35]=1)[C:30]([Cl:32])=[O:31]>>[OH2:14].[ClH:32].[F:26][C:27]1[CH:28]=[C:29]([CH:33]=[CH:34][CH:35]=1)[C:30]([NH:25][C:20]1[C:19]([NH:18][NH:17][C:15]([O:14][CH2:13][CH:10]2[CH2:9][CH2:8][N:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)[CH2:12][CH2:11]2)=[O:16])=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:31]

Participants

3

Reactant 2

HCID 743763-Fluorobenzoyl chlorideHCID 18174491HCID 18174491, compound

Product 1

HCID 86759101HCID 86759101, compoundYield 96.2%

Procedure

Using the procedure described in Example 48, Part C, N1-[[1-(4-pyridyl)piperidin-4-yl]methoxycarbonylamino]-1,2-benzenediamine (0.61 mmol) and 3-fluorobenzoyl chloride (1.2 mmol) yielded 152 mg (51%) of the title compound.

Sources & evidence

ORD record
ord-c4297f43db494c7abde1df657296edd0
Source dataset
uspto-grants-2003_08
Patent number
US06605626B2

Reaction notes

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