反应详情

A solution of 2,3-bis[(4-methoxybenzoyl)amino]phenoxy 4-methoxybenzoate (7.75 g, 14.7 mmol) in methanol (100 mL) was cooled to ice-water bath temperature and 5 N aqueous sodium hydroxide solution (3.0 mL) was added. The reaction mixture was allowed to warm to room temperature and stirred for 72 hr. The reaction mixture was concentrated in vacuo and the resulting solid was dissolved in methylene chloride and washed with dilute aqueous hydrochloric acid, water, and saturated sodium chloride solution. The organic layer was dried (sodium sulfate), filtered, and concentrated in vacuo. Recrystallization of the residue from diethyl ether/hexane gave 2.3 g (40%) of the title product. mp 208-209° C.

1. additionwas added
2. concentrationThe reaction mixture was concentrated in vacuo
3. dissolutionthe resulting solid was dissolved in methylene chloride
4. washwashed with dilute aqueous hydrochloric acid, water, and saturated sodium chloride solution
5. dry with materialThe organic layer was dried (sodium sulfate)
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. customRecrystallization of the residue from diethyl ether/hexane