N-(2-Aminophenyl)-4-methoxybenzamide → N1-(4-methoxybenzoyl)-N2-(1,5-dioxo-5-morpholinopentyl)-1,2-benzenediamine

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Reaction Steps

Using the procedure described in Example 161, 5-oxo-5-morpholinopentanoic acid (166 mg, 0.826 mmol) was reacted with N1-(4-methoxybenzoyl)-1,2-benzenediamine. The reaction mixture was diluted with additional methylene chloride and washed with 1 N aqueous sodium hydroxide. The organic phase was washed with 1 N aqueous hydrochloric acid, dried (sodium sulfate), filtered, and concentrated in vacuo to provide 300 mg (85%) of the title compound as an amorphous white solid.

Provenance & Evidence