2-amino-N-(4-methoxyphenyl)benzamide → N-(4-Methoxyphenyl)-2-[(1,5-dioxo-5-morpholinopentyl)amino]benzamide

HRID 395811Notes

Reaction equation

HRID 395811 reaction equation
[O:1]=[C:2]([N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)[CH2:3][CH2:4][CH2:5][C:6]([OH:8])=O.[NH2:15][C:16]1[CH:32]=[CH:31][CH:30]=[CH:29][C:17]=1[C:18]([NH:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=1)=[O:19]>>[CH3:28][O:27][C:24]1[CH:23]=[CH:22][C:21]([NH:20][C:18](=[O:19])[C:17]2[CH:29]=[CH:30][CH:31]=[CH:32][C:16]=2[NH:15][C:6](=[O:8])[CH2:5][CH2:4][CH2:3][C:2](=[O:1])[N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 4788202-amino-N-(4-methoxyphenyl)benzamideHCID 157799485-Morpholin-4-YL-5-oxopentanoic acid

Product 1

HCID 18174490N-(4-Methoxyphenyl)-2-[(1,5-dioxo-5-morpholinopentyl)amino]benzamide

Procedure

Using the procedure described in Example 161, 5-oxo-5-morpholinopentanoic acid (166 mg, 0.826 mmol) and 2-amino-N-(4-methoxyphenyl)benzamide yielded, after recrystallization from ethyl acetate/hexanes, 220 mg (63%) of the title compound as a white amorphous solid.

Workup

  1. customyielded
  2. customafter recrystallization from ethyl acetate/hexanes, 220 mg (63%) of the title compound as a white amorphous solid

Sources & evidence

ORD record
ord-96fe3aa99d3c425c9d850ccbdf812a7a
Source dataset
uspto-grants-2003_08
Patent number
US06605626B2

Reaction notes

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