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5-(Tert-butyldimethylsilyloxy)-2-phthalimido-1-nitrobenzene → 5-(Tert-butyldimethylsilyloxy)-2-phthalimidoaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-(Tert-butyldimethylsilyloxy)-2-phthalimido-1-nitrobenzene | HCID 18174472 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 5-(Tert-butyldimethylsilyloxy)-2-phthalimidoaniline | HCID 18174494 | 89% |
反応手順
A suspension of 5-(tert-butyldimethylsilyloxy)-2-phthalimido-1-nitrobenzene (5.00 g, 12.5 mmol) and 10% palladium-on-carbon (2.5 g) in ethyl acetate (60 mL) was stirred under 1 atm of hydrogen for 16 h. The mixture was filtered through a pad of diatomaceous earth and concentrated in vacuo to yield 4.1 g (89%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06605626B2 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-2c00665f62a2428faebe29f8a0010df9 |
| 出典メモ | uspto-grants-2003_08 |