HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Pyridinyl)-4-piperidinecarbonyl chloride → 5-Fluoro-2-[[1-(4-pyridyl)piperidin-4-ylcarbonyl]amino]-N-(4-methoxyphenyl)benzamide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Pyridinyl)-4-piperidinecarbonyl chloride | HCID 11183700 | — |
| Reactant | N-(4-methoxyphenyl)-2-amino-5-fluorobenzamide | HCID 18174421 | — |
| Product | 5-Fluoro-2-[[1-(4-pyridyl)piperidin-4-ylcarbonyl]amino]-N-(4-methoxyphenyl)benzamide Hydrochloride | HCID 18174636 | 58% |
Reaction Steps
Using the procedure described in Example 138, N-(4-methoxyphenyl)-2-amino-5-fluorobenzamide (1.8 mmol) and N-(4-pyridyl)isonipecotoyl chloride (3.6 mmol), purifying with RPHPLC Method A, yielded 500 mg (58%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06605626B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-248c1a95c73b4552b15c76c4f9ba7551 |
| Source note | uspto-grants-2003_08 |