2-Amino-N-phenylbenzamide → 2-[[1-(4-Pyridyl)piperidin-4-ylcarbonyl]amino]-N-phenylbenzamide Hydrochloride

HRID 395825Notes

Reaction equation

HRID 395825 reaction equation
[C:1]1([NH:7][C:8](=[O:16])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH2:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:17]1[CH:22]=[CH:21][C:20]([N:23]2[CH2:31][CH2:30][CH:26]([C:27]([Cl:29])=[O:28])[CH2:25][CH2:24]2)=[CH:19][CH:18]=1>>[ClH:29].[N:17]1[CH:22]=[CH:21][C:20]([N:23]2[CH2:24][CH2:25][CH:26]([C:27]([NH:15][C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:8]([NH:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[O:16])=[O:28])[CH2:30][CH2:31]2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 781422-Amino-N-phenylbenzamideHCID 111837001-(4-Pyridinyl)-4-piperidinecarbonyl chloride

Product 1

HCID 181745402-[[1-(4-Pyridyl)piperidin-4-ylcarbonyl]amino]-N-phenylbenzamide HydrochlorideYield 55%

Procedure

Using the procedure described in Example 138, N-phenyl-2-aminobenzamide (0.97 mmol) and N-(4-pyridyl)isonipecotoyl chloride (1.9 mmol), purifying with RPHPLC Method A, yielded 233 mg (55%) of the title compound.

Workup

  1. custompurifying with RPHPLC Method A

Sources & evidence

ORD record
ord-aaf2d09e03f742e68a11ae1b7b6a6322
Source dataset
uspto-grants-2003_08
Patent number
US06605626B2

Reaction notes

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