HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-amino-N-(4-chlorophenyl)benzamide → 2-[[1-(4-Pyridyl)piperidin-4-ylcarbonyl]amino]-N-(4-chlorophenyl)benzamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-amino-N-(4-chlorophenyl)benzamide | HCID 670472 | — |
| Reactant | 1-(4-Pyridinyl)-4-piperidinecarbonyl chloride | HCID 11183700 | — |
| Product | 2-[[1-(4-Pyridyl)piperidin-4-ylcarbonyl]amino]-N-(4-chlorophenyl)benzamide hydrochloride | HCID 18174538 | 146.1% |
Reaction Steps
Using the procedure described in Example 138, N-(4-chlorophenyl)-2-aminobenzamide (0.97 mmol) and N-(4-pyridyl)isonipecotoyl chloride (1.8 mmol), purifying with RPHPLC Method A, yielded 334 mg (37%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06605626B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-708870c1e3104e6da507b364addd0bab |
| Source note | uspto-grants-2003_08 |